For Product Sampling and Storage Applications Single-use molded manifolds are custom made to meet your product sampling and storage needs in drug and vaccine production. Designs range from simple molded sanitary ends to complex configurations with varying lengths of tubing and several molded connections. Single use molded manifolds are not intended for implantation or continuous steam applications. Leaks, entrapment, and contamination concerns involved with barbed fitting connections are eliminated.
Inexpensive, slow, low quality, energy intensive Vacuum evaporation multiple effect Good quality, energy efficient, costly equipment Freeze concentration High quality, slow, costly equipment, limited solids attainable Reverse osmosis High quality, slow, costly equipment, limited solids, clear only Electrodialysis High quality, slow, costly equipment, limited solids, clear only Since vacuum concentration strips the natural aroma from the juice, quality suffered.
Essence recovery and add back was an improved solution. Although in the absence of recovered essence, juice added back is an effective solution.
Water removal as affected by concentration greatly simplifies juice handling, storage and shipping logistics. High Brix is limited by viscosity build up due to the presence of pectin substances and insoluble solids or pulp. In the concentrated and frozen or refrigerated form the juice can be held for extended periods, shipped, or stockpiled for future use.
Indeed, the global trade in frozen concentrate has profoundly influenced juice and juice beverage developments, since long term stability and ease of transport make concentrates a readily available commodity.
Concentrates must be maintained cool, if not frozen to prevent quality loss primarily Maillard browning type reactions affecting colour and flavour. Three can volumes of water added for reconstitution.
Although traditional jelly making relied on the natural pectin present in fruits, commercially standardized pectin is invariably added in commercial operations.
The process is related to concentration, as the juice is partially concentrated and sugar is added to increase the solids level to above 65 percent. Combined with pectin and acid and hot filled, jellies are reasonably shelf stable and, along with the pectin derived from certain fruits can be considered a co-product of juice manufacture Chapters 11 and As with other concentration methods, the use of vacuum concentration during boil down and rapid filling and cooling, dramatically increases jelly quality.
Quality and efficiency considerations now favour vacuum systems in large throughput operations, although open steam kettles suffice in small niche markets. The key to open kettle jelly manufacture is: Although the combination of low pH, high solids and hot fill eliminates microbial spoilage, an opened container can be recontaminated by sugar-tolerant mould.
Also, high temperatures during preparation or subsequent storage reduced quality. Ultimately Maillard darkening and off flavour development occurred.
Very delicate fruits make acceptable jelly, but the flavour is far removed from the fresh or gently processed juice product.
Low calorie jelly is even more difficult to manufacture and store. Low methoxy pectin and calcium salts or other gel systems that are not dependent upon high sugar level provide adequate gel set.
However, such systems are more susceptible to post process contamination and require refrigeration after opening.
Indeed, wine was originally spoiled fruit juice that over the millennia was appreciated and perfected long before juices were refined. Actually, the technical and lay literature devoted to wine far exceeds the total treatment of all juices and similar beverages combined. Wine is briefly mentioned here since it represents a high value added product from fruits and also a step in the manufacture of vinegar, a logical by-product of juice manufacture.
The biquitous presence of all types of microbes, the sugar and nutrient content of fruits and generally low pH provides an ideal environment for "something" to grow.
Airborne, that something will no doubt be mould, with an unsightly mass of mycelia and offensive odours.
However, below the surface where oxygen is limited, yeast growth is likely, resulting in the production of ethyl alcohol and carbon dioxide gas. The classic Gay-Lussac equation is an over simplified but stociometrically reasonable depiction of the transformation of fermentable fruit sugars to ethanol and CO2 Figure 8.
Wine manufacture is challenging, relatively straightforward and well treated in classic texts Amerine, et al. Many of the steps inherent in juice production also apply to wine, including selection of fruit and attention to quality and sanitation.
Fruits do not necessarily have to be peeled, cored, deseeded, pressed, etc. Light coloured fruits are best pressed soon after crushing and treated with about ppm sulphur dioxide to prevent browning. Even here, clarification is not required until after the fermentation, SO2 also serves to inhibit spurious microbial growth, In the case of coloured fruits where pigment extraction into the must unfermented juice properly adjusted for fermentation is desired, the initial phase of fermentation serves to extract colour and soften the crushed material by natural enzyme activitythus increasing press yield.
This is one advantage of wine over juice; by setting the proper conditions and yeast inoculation, fermentation can proceed, thereby preventing microbial spoilage.
In addition, the evolving CO2 serves to exclude oxygen and the alcohol build up further limits competing microbes. The type of yeast is important.The cell therapy industry (CTI) is poised to grow rapidly over the next decade, treating millions of patients and generating annual revenues into the tens of billions of US dollars (1, 2).
To meet that high-growth demand, large CTI system manufacturers (e.g., Corning, Nunc/Nalgene, and GE Healthcare. AdvantaFlex® BioPharmaceutical Grade TPE Tubing. AdvantaFlex addresses the need for a flexible, translucent, sterilizable, heat sealable, weldable and moldable biopharmaceutical tubing for fluid processing..
AdvantaFlex is ideal for aseptic tubing welds, as it eliminates costly aseptic connectors and multiple contact surfaces. For a nonsterile compendial drug product that includes an antimicrobial preservative in its formulation, may I release and market lots of this drug product with initial out-of-specification total.
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Preservation with sugar. Contents - Previous - Next. The principle of this technology is to add sugar in a quantity that is necessary to augment the osmotic pressure of the product's liquid phase at a level which will prevent microorganism development.